Exposome-omics-Wide Association Study (ExWAS)

This web application can be used to query and download findings from the Exposome-omics-Wide Association Study (ExWAS) conducted in the Human Early Life Exposome (HELIX) project, including 1,301 school-age children from 6 European cohorts in the UK, France, Spain, Lithuania, Norway and Greece (https://www.projecthelix.eu").
This is a unique and comprehensive resource of molecular signatures related to common environmental exposures during vulnerable early life stages. Maitre, L., Bustamante, M., Hernandez-Ferrer, C. et al. Mutil-omics signatures of the human early life exposome. Nat Commun 13, 7024 (2022).https://doi.org/10.1038/s41467-022-34422-2

Scroll down to download other HELIX results.


Together with the ExWAS catalogue, we provide links to summarized results of other omics analyses in HELIX. To download summarized results, click on the links below.

Study Codebook Result tables Filesize
In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children (PMID: 32811491) HELIX_smok_omics_READMEfile.xlsx HELIX_smok_omics_WebCat.tar.gz 68M
Urinary metabolite quantitative trait loci in children and their interaction with dietary factors (PMID: 33283231) HELIX_urine_metabQTL_READMEfile.xlsx HELIX_urine_metabQTL_WebCat.tar.gz 511M
Identification of blood autosomal cis-expression quantitative trait methylation (cis-eQTMs) in children HELIX_Blood_eQTM_READMEfile.xlsx eQTM_autosome_adj.cells_SIG.txt.gz
Green space exposure and blood DNA methylation at birth and in childhood - a multi-cohort study EWAS_GS_blood_READMEfile.xlsx EWAS_GS_blood_summarized_results.zip 199M
Blood miRNA quantitative trait loci (blood miQTL) Coming soon Coming soon Not available

HELIX: This research received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 308333–the HELIX project.

ATHLETE: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874583

We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program